Spinal Dogma Part 2


Here’s the second part of my attempt to deconstruct the dogma and search for the evidence supporting out current management of suspected spinal cord injuries n prehospital care.

Scenario 2:

An aeromedical retrieval team attends a high speed road traffic crash in a rural area 250km from the nearest hospital.  The only seriously injured patient has just been extricated from the car by local ambulance and rescue crews as they arrive.  He is a man in his 20s with a GCS of 8 (M5), RR 20, SpO2 88% on NRBM, P 110, BP 100/60.  He has obvious external chest injuries, an unstable pelvis and an obviously fractured right femur.  The retrieval doctor decides to perform RSI before the >1 hour flight to hospital.  There are no predictors of a difficult airway.  RSI is performed with ketamine and suxamethonium.  The front of the collar is undone and manual inline immobilization performed.  On the first look the paramedic gets a grade 4 view.  The second look by the doctor produces the same result.  The Sats are now 73%.  Should manual inline immobilization be removed in the hope of improving laryngeal exposure?

The medico-legally correct answer, of course, is no.  Manual in-line Stabilization (MILS, or MILI if you replace stabilization with immobilization) must be maintained at all costs once the collar is undone.  Which is funny because I always thought A came before D (I’ve never accepted the concept of A-little c).  So where is the evidence for MILS?  As you’d expect there isn’t much.  There is more than for prehospital spinal immobilization though.  But there seems to be just as much evidence against as there is for.  Manoach and Paladino did a great review of what literature there is in the Annals of Emergency Medicine in 2007.  They couldn’t find any randomized studies, but found a bunch of case series, studies on volunteers (usually patients having GAs for unrelated matters) and studies on cadavers.  The long and short of it is that they found a bit of evidence showing that MILS decreases cervical spine movement during laryngoscopy.  This was mostly X-Ray or flouroscopic data.  However, they also found just as many studies showing that laryngoscopy without MILS doesn’t cause a significant amount of cervical spine movement anyway and that MILS does little to prevent it.  Sounds like equipoise to me.  One study, in fact showed that the jaw thrust caused more c-spine movement than direct laryngoscopy!  These were of course all small studies using surrogate end points.  As I pointed out in the last post, we don’t really know if 2 degrees of neck extension during laryngoscopy will have any effect at all on an unstable spinal fracture.

The authors of this study also point out that MILS can cause harm by worsening glottic view at laryngoscopy.  This is well established and I don’t think anyone would doubt it.  And this in fact may actually lead to increased cervical spine movement, as the increasingly panicked intubator pulls harder and harder on that handle.

So here we have a treatment that;

  • Aims to prevent a condition that is very rare, and may not even exist
  • Quite possibly doesn’t work
  • Causes harm

So why are we still using it?

And is it justifiable to remove MILS in order to improve glottic view in a difficult intubation?  Well Ron Walls, who literally wrote the (excellent) book on emergency airway management, seems to to think so “…even for blunt injury with intact neurological examination, if strict cervical spine immobilization is preventing intubation and hypoxaemia is developing, judicious relaxation of the degree of immobilization to an extent just sufficient to permit intubation may be necessary, depending on the judgement of the airway manager.”

This well worded paragraph in Wall’s text highlights 2 important caveats – there must be no neurological findings to indicate a higher likelihood of cervical spine injury than in the average trauma patient, and the patient must be deteriorating with the current form of airway management.  Whatever your own opinion of MILS may be and whatever the evidence (or lack thereof) may say, it is still standard of care, in particular if the patient has a confirmed or strongly suspected cervical spine injury.  In fact the standard of care for these injuries is probably awake fibre/flexible optic intubation, but this is rarely appropriate in the emergency setting.

What about videolaryngoscopes?  They seem a pretty promising way to provide a better view without moving the neck too much.  A 2008 crossover study on elective anaesthesia patients in Anesthesia and Analgesia showed that they do improve view, but don’t decrease neck movement compared with direct laryngoscopy.  I wonder if improvements in technology will give us the solution.  There is currently a cheap, portable flexible bronchoscope on the market.  While I personally think it is somewhat hamstrung by its lack of a suction port, it wont be long before it has lots of friends.  It seems logical that flexible-optic intubation via a supra-glottic airway (SGA) is the best solution to airway management in trauma, and hopefully it will be studied soon.

What about transporting the patient with a SGA in situ.  The so-called “rapid sequence airway”.  This will undoubtedly work in a lot of patients. But what if they have pulmonary contusions and poor pulmonary compliance?  Well ironically having a collar in situ may actually help the SGA to function in this setting by increasing the peak airway pressure required before a leak develops.  Presumably the external compression of the neck soft tissues by the collar improves the fit of the GSA.  This has only been shown for the LMA supreme, a very popular SGA in prehospital care.  Maybe this is the way to go, with or without intubation via a flexible scope?

So, the scant amount of evidence is before you and the question remains, is it appropriate to remove MILS in order to improve laryngoscopic view?   If you have a trauma patient who you can’t intubate and are in a situation where flexible-optic laryngoscopy is unavailable or unfeasible, what should you do?  Should you fly the patient to hospital with a supraglottic airway (SGA) in situ?   Should you perform a surgical airway in preference to removing MILS in the hope of getting a better view?

I’m keen to use the lack of inhibitions provided by the anonymity of the internet to see what other would do in the scenario described at the start of this post.

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Spinal Dogma Part 1

Emergency care is rife with dogma, and perhaps none is more pervasive than the desire, almost to the exclusion of everything else, to prevent further injury to the spinal cord in a trauma patient who may have a spinal cord injury.  The “ATLS position” of walking into a scenario looking like a cross between a zombie and a dalek with hands outstretched ready to manually immobilize the cervical spine while the patient bleeds to death or obstructs his airway is still practiced by thousands the world over.  Paramedics in many jurisdictions still carry out full spinal immobilization on poor blighters who were involved in low speed nose to tails.  The paranoia is such that even otherwise sensible and intelligent practitioners are willing to throw any evidence that there might (or might not) be out the window so as to not upset the ATLS applecart.  Is it possible that in doing so they throw the baby out with bathwater by ignoring the potential harms caused by spinal immobilization?

Over the course of three (possibly slightly ranty) posts, we’ll use some common scenarios to help us have a look for some evidence.  To save myself from reinventing the wheel, a great deal of what is discussed here is distilled from a couple of recent excellent reviews of spine cord injury from ebmedicine.net which can be found here and here but I have gone back to uncover some original papers, some of which are amazing and I strongly encourage you to read.

Scenario 1

Paramedics are called to a high speed single vehicle road traffic crash.  The only occupant of the car has self extricated and is ambulant.  He appears to have a fractured right clavicle from his seatbelt (make it left if you’re in North America) and some superficial burns to his face from the airbag.  The car is extensively damaged.  Should he be immobilized for transfer to hospital?

Well I guess there are 2 questions here.  1) If this man has an occult spinal cord injury – will immobilization prevent any secondary harm to his spinal cord. 2) If this man does not have a secondary spinal cord injury, can paramedics in the field without access to imaging or other advanced diagnostic techniques rule out a significant cervical spine injury?

As you are probably already aware, there is an embarrassing lack of evidence for spinal immobilization as a technique to prevent secondary injury.  A (very short) Cochrane review back in 2001 screened 4453 pieces of literature and wasn’t able to find a single RCT of spinal immobilization.  The authors concluded that because of it’s ability to remove focus from the airway and potentially hinder airway care, cervical immobilization may even increase mortality.  Of course some may use this opportunity to put forth the parachute argument – “There’s never been an RCT of parachutes in preventing death when jumping out of planes.  Should we stop using them?”

In 1998 a pretty amazing study was published in Academic Emergency Medicine.  It retrospectively compared outcomes for trauma patients with spinal injuries in patients from Albuquerque, New Mexico, which at the time had an advanced EMS system and Kuala Lumpur, Malaysia; which at the time had no EMS system.  The authors hoped to find out if spinal immobilization had any effect on neurologic disability in patients with spinal cord injury.  The paper is freely available on the Academic Emergency Medicine website and I encourage you to have a look.  Over the 5 year (retrospective) study period the authors identified 334 (out of12,700) patients in New Mexico and 120 (out of16,600) in Malaysia who had a blunt injury to the spine. Of note all of the US patients were immobilized and none of the Malaysian patients were immobilized.  The distribution of injury level (cervical, thoracic, lumbar) was similar between the 2 groups.  More of the patients in the US group were injured in RTCs and more in the Malaysian group were injured in falls.

70 of 334 patients in the US group (21%) and 13 of the 120 patients in the Malaysian group (11%) had “significant neurologic disability.”  Wow.  So that’s an odds ratio of 2.03 for harm from spinal immobilization (CI 1.03-3.99, p=0.004).  This allowed the authors to conclude that “out-of-hospital immobilization has little or no effect on neurologic outcome in patients with blunt spinal injuries.”  The authors of this study found exactly the opposite of what we would all expect to find.

Again, wow.  Lets not get carried away though.  Lots of potential bias here.  Retrospective study.  Huge number of patients screened but relatively small number studied.  Patients not able to be matched for injury severity (no ISS in Malaysia at the time).  Possible survivor bias (all of the patients with severe spinal injuries in Malaysia may have died at the scene or during transport).  More RTCs in the US groups.  There lots to criticize.  But despite all of this, I like this study.  It looks at a question that most are afraid to ask, and gives an uncomfortable answer.

The study also raised some questions for me.  Firstly, how come it was published in 1998 and I only found out about it last week?  Second, why have I been putting collars on patients for the last 15 years?  Third, and more seriously – why hasn’t this intriguing retrospective, hypothesis generating study led to an RCT?

To ethically trial a treatment (or withholding of a treatment) in patients you need a plausible  theoretical mechanism of effect, and clinical equipoise.  The authors of this study point to research indicating that a force of over 2,000N is required to fracture a cervical vertebra and that even dangling the unsupported head off the end of the stretcher only generates 40N.  So theoretically it is plausible that all damage is done at the scene of the crash or fall and that any further movement after this will not cause harm.  It has also been shown that patients in collars will move more than those without collars as they try to adjust to a position of comfort (wear a collar for an hour and see how you like it).

What about equipoise?  Does this retrospective study give it?  I think it gives us the closest we’re ever going to get.  But I don’t think an RCT will ever be done.  It may not need to.  indiscriminate collar use has decreased a lot with the prehospital use of decision making tools such as the Canadian C-Spine Rules (CCR).  I still think collars cause harm, however.  They certainly cause bedsores.  They make airway management more difficult.  As mentioned above they may make awake patients move more.

What I think this study says is that spinal immobilization should be taken down off it’s pedestal and given the same critique that any old-fashioned treatment deserves.  A study around the same time as this one showed that MAST trousers didn’t work and may cause harm.  They were gone by lunchtime.  Why didn’t collars get the same treatment?

Enough ranting.  Lets get back to the real world.  I’m being realistic and accepting that collars are here to stay.  So can paramedics decide whether or not someone needs one?  Well it would appear so.  The NEXUS low-risk-criteria and the CCR are already well established in emergency medicine practice and have been shown to be safe and effective. In fact it has already been discussed  right here. Both rules have been prospectively validated by paramedics, with the CCR appearing more sensitive than NEXUS (100% sensitive in one study, with a follow up study under way).  As long as a decision support tool is well taught and there is effective clinical governance, there should be little risk involved.  The results of the study currently underway should be telling.  If the sensitivity approaches the 100% of the pilot, then there can be no excuse for EMS systems not to allow paramedics to use a clinical decision tool for spinal immobilization.

Stay tuned for part two, about the cervical spine and the airway. In the meantime,  why don’t you tell us what you think about this?

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Clinical Governance Day Wednesday 21st November 2012

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Prehospital RSI

Here are the slides of the presentation delivered by Dr Peter Sherren to ACAP NSW in October 2012

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Clinical Governance Day 10th October 2012

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Clinical Governance Day 26th September 2012

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Emergency Registrar Open Day

A Prehospital & Retrieval Medicine Training Day for emergency medicine registrars will be held at our base on Thursday 29th November 2012.

Details are below; click the image for a PDF of the flyer.

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Aeromedical Conference in Cairns

Some physicians and paramedics from the GSA-HEMS Team are in Cairns at the Aeromedical Society of Australasia and Flight Nurse Association Scientific Meeting.


They will be competing in the Retrieval Simulation Cup.

You can follow updates from the conference on Twitter via the hashtag #aeromed12 or by clicking here

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Clinical Governance Day 29th August 2012

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Clinical Governance Day 15th August 2012

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